Humane Genomics
We recently announced our first biotech investment at USV in a company called Humane Genomics . They engineer viruses that can be made to selectively infect different kinds of cells. To start, they’re focused on viruses that kill cancer cells [...] Read more
Against The End of History of Venture Capital
I’ve written previously about the deep tech opportunity . While lean software startups have been a great place to invest venture capital over the last thirty years, I believe we’re living through a shift where future returns in venture capital [...] Read more
Cactos
The dramatic reduction in the cost of solar energy means we can cheaply produce clean power– but only when the sun is out. Batteries are a natural companion to solar, capable of soaking up surplus energy when the sun is shining, [...] Read more
Presto
Electric vehicles are a prime example of how electricity will be used in more complex ways as we electrify everything to reduce carbon emissions. As batteries, they enable shifting electricity usage in time, and as vehicles, they enable shifting usage [...] Read more
Frame122
The Gotham Gal and I have completed another of our sustainable apartment buildings we make for families that live in Brooklyn. We call the building Frame122 and it is located at 122 Waverly Avenue , right off Myrtle Avenue, about [...] Read more
Four Futures
This post was originally published on the USV blog and can be found here . Co-authored with Rebecca Kaden , Nick Grossman , and Matt Mandel . We are in a moment where the future is both wildly exciting and [...] Read more
A Dark Forest of ASIs
I have already written a prior post arguing against Leopold Aschenbrenner 's logic for a Manhattan project to achieve artificial super intelligence (ASI). In that post I made the argument that having more than one system mitigates risks because we [...] Read more
The Deep Tech Opportunity
Modern venture history begins with General Georges Doriot’s American Research and Development (ARD) Corporation. ARD invested in a wide range of novel technologies, from off-shore oil and radiation detection to, most importantly, minicomputers. As Tom Nicholas notes in his VC: [...] Read more
Leon’s
I have always been a big fan of breakfast, lunch and dinner business meetings. There is something about breaking bread over a meeting, or a glass of wine or beer or a cup of coffee. The ideal location is a [...] Read more